Design, Development And Evaluation Of Transdermal Drug Delivery System For Treatment Of Diabetes

The current research aims to formulate and evaluated Cinnamaldehyde transdermal patches treat diabetes. A good penetration enhancer Oleic Acid, would improve drug delivery from various polymer-based patches. Transdermal of the matrix type were made by solvent casting techniques using polymer PVP K30, HPMC K100, solvent. All prepared formulations tested for folding endurance, weight variation, thickness, content, moisture loss, in vitro release In- vivo studies. Batch TDP1 was optimised formula all formulation batches shows zero order 24 hours, with a cumulative percentage diffusion 97.68% 2cm2 It has been determined that concentration films showed better which may be attributed reason high water vapour permeability enhancing rate through rat skin, oleic acid incorporated as permeation enhancers since they release. allows controlled patch. Drug content found more than 98%. Variations flux Diffusion Coefficient observed among formulations. drug–polymer interaction results suggested no between polymers. revealed successfully prevented hyperglycaemia also effective on chronic application. route exhibited negligible skin irritation produced improvement parameters compared oral administration.